TPIDB > 臨床試驗主持人
臨床試驗主持人
更新時間：2023-09-19
葉國偉YEH, KUO-WEI
- 計畫主持人
- 執行臨床試驗年資 23 年 9 個月
-
kjaecqaa@gmail.com
發表文獻
1筆
1
2020
1. Lai SH, Chiang MC, Chu SM, Hsu JF, Yao TC, Tsai MH, Hua MC, Chiu CY, Yeh KW, Huang JL, Liao SL. Evolution and Determinants of Lung Function until Late Infancy among Infants Born Preterm. Sci Rep. 2020 Jan 16;10(1):490. doi: 10.1038/s41598-019-57359-x. (SCI; IF=4.379; Multidisciplinary sciences 17/73, 23.2%)
2. Zhang-Jian SJ, Yang HY, Chiu MJ, Chou IJ, Kuo CF, Huang JL, Yeh KW, Wu CY. Pregnancy outcomes and perinatal complications of Asian mothers with juvenile idiopathic arthritis - a case-control registry study. Pediatr Rheumatol Online J. 2020 Jan 23;18(1):9. doi: 10.1186/s12969-020-0404-8. (SCI; IF=3.054; Pediatric 34/129; 26.4%)
3. Wei Choo CY, Yeh KW, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Chiu CY. Oxidative stress is associated with atopic indices in relation to childhood rhinitis and asthma. J Microbiol Immunol Infect. 2020 Feb 13:S1684-1182(20)30010-4. doi: 10.1016/j.jmii.2020.01.009. (SCI; IF=4.399; 28/92, Infection 30.4%)
4. Wu CY, Chien HP, Yang HY, Yao TC, Tseng MH, Yu MC, Yeh KW, Huang JL. Role of tubulointerstitial lesions in predicting renal outcome among pediatric onset lupus nephritis - A retrospective cohort study. J Microbiol Immunol Infect 2020 Feb;53(1):33-41 (SCI; IF=4.399; 28/92, Infection 30.4%)
5. Liou CJ, Chen YL, Yu MC, Yeh KW, Shen SC, Huang WC. Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice. Antioxidants (Basel). 2020 Apr 1;9(4):295. doi: 10.3390/antiox9040295. (SCI; IF=6.313, 11/144 Food Science and Technology, 7.6%)
6. Hsieh MY, Lin JJ, Hsia SH, Huang JL, Yeh KW, Chang KW, Lee WI. Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES). Biomed J. 2020 May 29:S2319-4170(20)30070-6. (SCI; IF=4.910; Biochemistry & Molecular Biology 95/297, 31.9%)
7. Lee WI, Huang JL, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Jaing TH, Shih YF, Wu CY.Lower T Regulatory and Th17 Cell Populations Predicted by RT-PCR-Amplified FOXP3 and RORγt Genes Are Not Rare in Patients With Primary Immunodeficiency Diseases. Front Immunol. 2020 Jun 25;11:1111. (SCI; IF=7.561, Immunology 24/162, 14.8%)
8. Tsai MH, Liao SL, Chiu CY, Shih HJ, Hua MC, Yao TC, Lai SH, Yeh KW, Chen LC, Chang YJ, Huang JL. Longitudinal investigation of nasopharyngeal pneumococcal carriage in early childhood: The PATCH birth cohort study. PLoS One. 2020 Aug 20;15(8):e0237871. (SCI; IF=3.240; Multidisclinary Science 26/73, 35.6% )
9. Lin TC, Kuo CC, Wu CY, Yeh KW, Kuo ML, Huang JL. The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study. J Microbiol Immunol Infect. 2020 Oct;53(5):797-802 (SCI; IF=4.399; 28/92, Infection 30.4%)
10. Liao SL, Chen LC, Tsai MH, Hua MC, Yao TC, Su KW, Yeh KW, Chiu CY, Lai SH, Huang JL. Prenatal exposure to bisphenol - A is associated with dysregulated perinatal innate cytokine response and elevated cord IgE level: a population-based birth cohort study. Environ Res. 2020 Sep 6:110123 (SCI; IF=6.498, Public, Environmental and Occupation Health 16/203 , 7.9%)
11. Yeh YH, Hsieh MY, Lee WI, Huang JL, Chen LC, Yeh KW, Ou LS, Yao TC, Wu CY, Lin SJ. Distinct Clinical Features and Novel Mutations in Taiwanese Patients With X-Linked Agammaglobulinemia. Front Immunol. 2020 Sep 4;11:2001 (SCI; IF=7.561, Immunology 24/162, 14.8%)
12. Chiu CY, Yang CH, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Yeh KW*, Huang JL. Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood. J Microbiol Immunol Infect. 2020 Dec;53(6):1008-1013. (SCI; IF=4.399; 28/92, Infection; 30.4%)
13. Wong CY, Yeh KW*, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Chiu CY. Longitudinal analysis of total serum IgE levels with allergen sensitization and atopic diseases in early childhood. Sci Rep. 2020 Dec 4;10(1):21278 (SCI; IF=4.379; Multidisciplinary sciences 17/73; 23.2%)
2021
14. Gau CC, Yao TC, Gan ST, Lin SJ, Yeh KW, Chen LC, Ou LS, Lee WI, Wu CY, Huang JL. Age, gender, height and weight in relation to joint cartilage thickness among school-aged children from ultrasonographic measurement. Pediatr Rheumatol Online J. 2021 May 12;19(1):71. doi: 10.1186/s12969-021-00554-w (SCI; IF=3.054; Pediatric 34/129; 26.4%)
15. Wu SJ, Huang WC, Yu MC, Chen YL, Shen SC, Yeh KW, Liou CJ. Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. J Nutr Biochem. 2021 May;91:108602. doi: 10.1016/j.jnutbio.2021.108602. (SCI; IF=6.048; Nutrition & Dietetics 16/88; 17.0%)
16. Chen LC, Tseng HM, Kuo ML, Chiu CY, Liao SL, Su KW, Tsai MH, Hua MC, Lai SH, Yao TC, Yeh KW, Wu AH, Yu HY, Huang JL, Huang SK. Levels of 15-HETE and TXB2 in exhaled breath condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr Allergy Immunol. 2021 Jun 27. doi: 10.1111/pai.13587. (SCI; IF=6.377; Pediatrics 5/129, 3.9%)
17. Lai SH, Tsai MH, Hua MC, Yeh KW, Yao TC, Huang JL, Liao SL. Distinct lung function and bronchodilator responses between term and preterm young children with recurrent wheezing. Pediatr Neonatol. 2021 Jul;62(4):394-399. (SCI; IF=2.083; Pediatric 71/129; 55.0%)
18. Wu CY, Huang HY, Pan WC, Liao SL, Hua MC, Tsai MH, Lai SH, Yeh KW, Chen LC, Huang JL, Yao TC Allergic diseases attributable to atopy in a population sample of Asian children. Sci Rep. 2021 Aug 6;11(1):16052. doi: 10.1038/s41598-021-95579-2. (SCI; IF=4.379; Multidisciplinary sciences 17/73, 23.2%)
19. Yeh KW, Chen CT, Lee PC, Huang JL, Yan DC, Chen LC, Lin SJ, Yao TC, Wu CD, Wan GH. Outdoor air pollutants exposure associated with pulmonary function and exhaled breath condensate pH value in atopic asthmatic and non-asthmatic children. J Asthma. 2021 Oct;58(10):1278-1284. (SCI; IF=2.515; 21/28, Allergy 75.0%)
20. Tsai MH, Chiu CY, Su KW, Liao SL, Shih HJ, Hua MC, Yao TC, Lai SH, Yeh KW, Chen LC, Huang JL. Community-Associated Methicillin-Resistant Staphylococcus Aureus Colonization in a Birth Cohort of Early Childhood: The Role of Maternal Carriage. Front Med (Lausanne). 2021 Oct 26;8:738724.
21. Huang WC, Huang TH, Yeh KW, Chen YL, Shen SC, Liou CJ. Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice.. J Ginseng Res. 2021 Nov;45(6):654-664.
22. Sung WH, Yeh KW, Huang JL, Su KW, Chen KF, Wu CC, Tsai MH, Hua MC, Liao SL, Lai SH, Chiu CY. Longitudinal changes in body mass index Z-scores during infancy and risk of childhood allergies. J Microbiol Immunol Infect. 2021 Oct 25:S1684-1182(21)00228-0.
2022
23. Tang CM, Lin G, Chiang MH, Yeh KW, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chiu CY. Longitudinal Metabolomic Analysis Reveals Gut Microbial-Derived Metabolites Related to Formula Feeding and Milk Sensitization Development in Infancy. Metabolites. 2022 Jan 28;12(2):127.
24. Su KW, Chiu CY, Tsai MH, Liao SL, Chen LC, Hua MC, Yao TC, Huang JL, Yeh KW*; PATCH study group. Cord blood soluble Fas ligand linked to allergic rhinitis and lung function in seven-year-old children. J Microbiol Immunol Infect. J Microbiol Immunol Infect. 2022 Apr;55(2):300-306 (SCI; IF=4.399; 28/92, Infection 30.4%)
25. Chang YH, Yeh KW, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Chiu CY. Metabolomics analysis reveals molecular linkages for the impact of vitamin D on childhood allergic airway diseases. Pediatr Allergy Immunol. 2022 May;33(5):e13785. doi: 10.1111/pai.13785.
26. Hua MC, Chen CC, Liao SL, Yao TC, Tsai MH, Lai SH, Su KW, Chen LC, Chiu CY, Yeh KW, Huang JL Increased fecal human beta-defensin-2 expression in preterm infants is associated with allergic disease development in early childhood. World Allergy Organ J. 2022 May 11;15(5):100633
27. Wang MC, Huang WC, Chen LC, Yeh KW, Lin CF, Liou CJ. Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model. Int J Mol Sci. 2022 May 29;23(11):6104
28. Yu CY, Kuo CF, Chou IJ, Chen JS, Lu HY, Wu CY, Chen LC, Huang JL, Yeh KW*. Comorbidities of systemic lupus erythematosus prior to and following diagnosis in different age-at-onset groups. Lupus. 2022 Jul;31(8):963-973
29. Huang WC, Wu SJ, Yeh KW, Liou CJ Gypenoside A from Gynostemma pentaphyllum Attenuates Airway Inflammation and Th2 Cell Activities in a Murine Asthma Model.. Int J Mol Sci. 2022 Jul 12;23(14):7699.
30. Tsai MH, Shih HJ, Su KW, Liao SL, Hua MC, Yao TC, Lai SH, Yeh KW, Chen LC, Huang JL, Chiu CY. Nasopharyngeal microbial profiles associated with the risk of airway allergies in early childhood. J Microbiol Immunol Infect. 2022 Aug;55(4):777-785
31. Wen TN, Lin HC, Yeh KW, Huang JL, Chiang LC.Effectiveness of eAsthmaCare on Symptoms, Childhood Asthma Control Test, and Lung Function among Asthmatic Children. J Med Syst. 2022 Sep 26;46(11):71.
32. Wu CY, Fan WL, Yang HY, Chu PS, Liao PC, Chen LC, Yao TC, Yeh KW, Ou LS, Lin SJ, Lee WI, Huang JL. Contribution of genetic variants associated with primary immunodeficiencies to childhood-onset systemic lupus erythematous. J Allergy Clin Immunol. 2022 Dec 28:S0091-6749(22)02558-1. doi: 10.1016/j.jaci.2022.12.807. Online ahead of print.
1. Lai SH, Chiang MC, Chu SM, Hsu JF, Yao TC, Tsai MH, Hua MC, Chiu CY, Yeh KW, Huang JL, Liao SL. Evolution and Determinants of Lung Function until Late Infancy among Infants Born Preterm. Sci Rep. 2020 Jan 16;10(1):490. doi: 10.1038/s41598-019-57359-x. (SCI; IF=4.379; Multidisciplinary sciences 17/73, 23.2%)
2. Zhang-Jian SJ, Yang HY, Chiu MJ, Chou IJ, Kuo CF, Huang JL, Yeh KW, Wu CY. Pregnancy outcomes and perinatal complications of Asian mothers with juvenile idiopathic arthritis - a case-control registry study. Pediatr Rheumatol Online J. 2020 Jan 23;18(1):9. doi: 10.1186/s12969-020-0404-8. (SCI; IF=3.054; Pediatric 34/129; 26.4%)
3. Wei Choo CY, Yeh KW, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Chiu CY. Oxidative stress is associated with atopic indices in relation to childhood rhinitis and asthma. J Microbiol Immunol Infect. 2020 Feb 13:S1684-1182(20)30010-4. doi: 10.1016/j.jmii.2020.01.009. (SCI; IF=4.399; 28/92, Infection 30.4%)
4. Wu CY, Chien HP, Yang HY, Yao TC, Tseng MH, Yu MC, Yeh KW, Huang JL. Role of tubulointerstitial lesions in predicting renal outcome among pediatric onset lupus nephritis - A retrospective cohort study. J Microbiol Immunol Infect 2020 Feb;53(1):33-41 (SCI; IF=4.399; 28/92, Infection 30.4%)
5. Liou CJ, Chen YL, Yu MC, Yeh KW, Shen SC, Huang WC. Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice. Antioxidants (Basel). 2020 Apr 1;9(4):295. doi: 10.3390/antiox9040295. (SCI; IF=6.313, 11/144 Food Science and Technology, 7.6%)
6. Hsieh MY, Lin JJ, Hsia SH, Huang JL, Yeh KW, Chang KW, Lee WI. Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES). Biomed J. 2020 May 29:S2319-4170(20)30070-6. (SCI; IF=4.910; Biochemistry & Molecular Biology 95/297, 31.9%)
7. Lee WI, Huang JL, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Jaing TH, Shih YF, Wu CY.Lower T Regulatory and Th17 Cell Populations Predicted by RT-PCR-Amplified FOXP3 and RORγt Genes Are Not Rare in Patients With Primary Immunodeficiency Diseases. Front Immunol. 2020 Jun 25;11:1111. (SCI; IF=7.561, Immunology 24/162, 14.8%)
8. Tsai MH, Liao SL, Chiu CY, Shih HJ, Hua MC, Yao TC, Lai SH, Yeh KW, Chen LC, Chang YJ, Huang JL. Longitudinal investigation of nasopharyngeal pneumococcal carriage in early childhood: The PATCH birth cohort study. PLoS One. 2020 Aug 20;15(8):e0237871. (SCI; IF=3.240; Multidisclinary Science 26/73, 35.6% )
9. Lin TC, Kuo CC, Wu CY, Yeh KW, Kuo ML, Huang JL. The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study. J Microbiol Immunol Infect. 2020 Oct;53(5):797-802 (SCI; IF=4.399; 28/92, Infection 30.4%)
10. Liao SL, Chen LC, Tsai MH, Hua MC, Yao TC, Su KW, Yeh KW, Chiu CY, Lai SH, Huang JL. Prenatal exposure to bisphenol - A is associated with dysregulated perinatal innate cytokine response and elevated cord IgE level: a population-based birth cohort study. Environ Res. 2020 Sep 6:110123 (SCI; IF=6.498, Public, Environmental and Occupation Health 16/203 , 7.9%)
11. Yeh YH, Hsieh MY, Lee WI, Huang JL, Chen LC, Yeh KW, Ou LS, Yao TC, Wu CY, Lin SJ. Distinct Clinical Features and Novel Mutations in Taiwanese Patients With X-Linked Agammaglobulinemia. Front Immunol. 2020 Sep 4;11:2001 (SCI; IF=7.561, Immunology 24/162, 14.8%)
12. Chiu CY, Yang CH, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Yeh KW*, Huang JL. Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood. J Microbiol Immunol Infect. 2020 Dec;53(6):1008-1013. (SCI; IF=4.399; 28/92, Infection; 30.4%)
13. Wong CY, Yeh KW*, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Chiu CY. Longitudinal analysis of total serum IgE levels with allergen sensitization and atopic diseases in early childhood. Sci Rep. 2020 Dec 4;10(1):21278 (SCI; IF=4.379; Multidisciplinary sciences 17/73; 23.2%)
2021
14. Gau CC, Yao TC, Gan ST, Lin SJ, Yeh KW, Chen LC, Ou LS, Lee WI, Wu CY, Huang JL. Age, gender, height and weight in relation to joint cartilage thickness among school-aged children from ultrasonographic measurement. Pediatr Rheumatol Online J. 2021 May 12;19(1):71. doi: 10.1186/s12969-021-00554-w (SCI; IF=3.054; Pediatric 34/129; 26.4%)
15. Wu SJ, Huang WC, Yu MC, Chen YL, Shen SC, Yeh KW, Liou CJ. Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. J Nutr Biochem. 2021 May;91:108602. doi: 10.1016/j.jnutbio.2021.108602. (SCI; IF=6.048; Nutrition & Dietetics 16/88; 17.0%)
16. Chen LC, Tseng HM, Kuo ML, Chiu CY, Liao SL, Su KW, Tsai MH, Hua MC, Lai SH, Yao TC, Yeh KW, Wu AH, Yu HY, Huang JL, Huang SK. Levels of 15-HETE and TXB2 in exhaled breath condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr Allergy Immunol. 2021 Jun 27. doi: 10.1111/pai.13587. (SCI; IF=6.377; Pediatrics 5/129, 3.9%)
17. Lai SH, Tsai MH, Hua MC, Yeh KW, Yao TC, Huang JL, Liao SL. Distinct lung function and bronchodilator responses between term and preterm young children with recurrent wheezing. Pediatr Neonatol. 2021 Jul;62(4):394-399. (SCI; IF=2.083; Pediatric 71/129; 55.0%)
18. Wu CY, Huang HY, Pan WC, Liao SL, Hua MC, Tsai MH, Lai SH, Yeh KW, Chen LC, Huang JL, Yao TC Allergic diseases attributable to atopy in a population sample of Asian children. Sci Rep. 2021 Aug 6;11(1):16052. doi: 10.1038/s41598-021-95579-2. (SCI; IF=4.379; Multidisciplinary sciences 17/73, 23.2%)
19. Yeh KW, Chen CT, Lee PC, Huang JL, Yan DC, Chen LC, Lin SJ, Yao TC, Wu CD, Wan GH. Outdoor air pollutants exposure associated with pulmonary function and exhaled breath condensate pH value in atopic asthmatic and non-asthmatic children. J Asthma. 2021 Oct;58(10):1278-1284. (SCI; IF=2.515; 21/28, Allergy 75.0%)
20. Tsai MH, Chiu CY, Su KW, Liao SL, Shih HJ, Hua MC, Yao TC, Lai SH, Yeh KW, Chen LC, Huang JL. Community-Associated Methicillin-Resistant Staphylococcus Aureus Colonization in a Birth Cohort of Early Childhood: The Role of Maternal Carriage. Front Med (Lausanne). 2021 Oct 26;8:738724.
21. Huang WC, Huang TH, Yeh KW, Chen YL, Shen SC, Liou CJ. Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice.. J Ginseng Res. 2021 Nov;45(6):654-664.
22. Sung WH, Yeh KW, Huang JL, Su KW, Chen KF, Wu CC, Tsai MH, Hua MC, Liao SL, Lai SH, Chiu CY. Longitudinal changes in body mass index Z-scores during infancy and risk of childhood allergies. J Microbiol Immunol Infect. 2021 Oct 25:S1684-1182(21)00228-0.
2022
23. Tang CM, Lin G, Chiang MH, Yeh KW, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chiu CY. Longitudinal Metabolomic Analysis Reveals Gut Microbial-Derived Metabolites Related to Formula Feeding and Milk Sensitization Development in Infancy. Metabolites. 2022 Jan 28;12(2):127.
24. Su KW, Chiu CY, Tsai MH, Liao SL, Chen LC, Hua MC, Yao TC, Huang JL, Yeh KW*; PATCH study group. Cord blood soluble Fas ligand linked to allergic rhinitis and lung function in seven-year-old children. J Microbiol Immunol Infect. J Microbiol Immunol Infect. 2022 Apr;55(2):300-306 (SCI; IF=4.399; 28/92, Infection 30.4%)
25. Chang YH, Yeh KW, Huang JL, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Chiu CY. Metabolomics analysis reveals molecular linkages for the impact of vitamin D on childhood allergic airway diseases. Pediatr Allergy Immunol. 2022 May;33(5):e13785. doi: 10.1111/pai.13785.
26. Hua MC, Chen CC, Liao SL, Yao TC, Tsai MH, Lai SH, Su KW, Chen LC, Chiu CY, Yeh KW, Huang JL Increased fecal human beta-defensin-2 expression in preterm infants is associated with allergic disease development in early childhood. World Allergy Organ J. 2022 May 11;15(5):100633
27. Wang MC, Huang WC, Chen LC, Yeh KW, Lin CF, Liou CJ. Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model. Int J Mol Sci. 2022 May 29;23(11):6104
28. Yu CY, Kuo CF, Chou IJ, Chen JS, Lu HY, Wu CY, Chen LC, Huang JL, Yeh KW*. Comorbidities of systemic lupus erythematosus prior to and following diagnosis in different age-at-onset groups. Lupus. 2022 Jul;31(8):963-973
29. Huang WC, Wu SJ, Yeh KW, Liou CJ Gypenoside A from Gynostemma pentaphyllum Attenuates Airway Inflammation and Th2 Cell Activities in a Murine Asthma Model.. Int J Mol Sci. 2022 Jul 12;23(14):7699.
30. Tsai MH, Shih HJ, Su KW, Liao SL, Hua MC, Yao TC, Lai SH, Yeh KW, Chen LC, Huang JL, Chiu CY. Nasopharyngeal microbial profiles associated with the risk of airway allergies in early childhood. J Microbiol Immunol Infect. 2022 Aug;55(4):777-785
31. Wen TN, Lin HC, Yeh KW, Huang JL, Chiang LC.Effectiveness of eAsthmaCare on Symptoms, Childhood Asthma Control Test, and Lung Function among Asthmatic Children. J Med Syst. 2022 Sep 26;46(11):71.
32. Wu CY, Fan WL, Yang HY, Chu PS, Liao PC, Chen LC, Yao TC, Yeh KW, Ou LS, Lin SJ, Lee WI, Huang JL. Contribution of genetic variants associated with primary immunodeficiencies to childhood-onset systemic lupus erythematous. J Allergy Clin Immunol. 2022 Dec 28:S0091-6749(22)02558-1. doi: 10.1016/j.jaci.2022.12.807. Online ahead of print.
