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Principal Investigator


Linkou Chang Gung Medical Foundation (在職)

Division of Orthopedics

更新時間:2023-09-19

張毓翰Chang, Yu-Han
  • Principal Investigator
  • Clinical Trial Experience (year) 23 years 9 個月
  • yhchang@cgmh.org.tw

Publication

21Publications

1

Chang CW, Wang LS, Pham NN, Shen CC, Hsu MN, Nguyen NTK, Yen CY, Lin MW, Hwu JR, Chang YH*, Hu YC. Synthetic biology approach to developing all-in-one baculovirus vector using mammalian introns and miRNA binding sites. Journal of the Taiwan Institute of Chemical Engineers. 2022 Feb; 131:10417 (SCI, IF:5.876, Engineering, Chemical, Rank: 25/143) (Corresponding author)

2

Vu Anh Truong, Ya-Hui Lin, Nuong Thi Kieu Nguyen, Mu-Nung Hsu, Nam Ngoc Pham, Yi-Hao Chang, Chin-Wei Chang, Chih-Che Shen, Hsiang-Sheng Lee, Po-Liang Lai, Yelena V Parfyonova 3, Mikhail Menshikov, Jaw-Ching Wu, Chang YH*, Yu-Chen Hu. Bi-directional gene activation and repression promote ASC differentiation and enhance bone healing in osteoporotic rats. Mol Ther. 2022 Jan 5;30(1):92-104. (SCI, IF:11.454, Biotechnology & Applied Microbiology, Rank: 11/140)(Corresponding author)

3

Cheng Fong Chen, Chih Chien Hu, Chen Te Wu , Hung Ta H. Wu, Chun Shin Chang, Yi Pei Hung, Chia Chu Tsai and Yu-han Chang. Treatment of knee osteoarthritis with intra-articular injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE®: a phase I/II, randomized, active-control, single-blind, multiple-center clinical trial. Stem Cell Res Ther (2021) 12:562.

4

Cheng-Fong Chen, Chih-Chien Hu, Chen-Te Wu, Hung-Ta H Wu, Chun-Shin Chang, Yi-Pei Hung, Chia-Chu Tsai, Chang YH*. Treatment of knee osteoarthritis with intra-articular injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE®: a phase I/II, randomized, active-control, single-blind, multiple-center clinical trial. Stem Cell Res Ther. 2021 Oct 30;12(1):562. (SCI, IF: 6.832, Cell Biology, Rank: 40/201) (Corresponding author)

5

Nuong Thi Kieu Nguyen, Chang YH, Vu Anh Truong, Mu-Nung Hsu, Nam Ngoc Pham, Chin-Wei Chang, Yi-Hsiu Wu, Yi-Hao Chang, Hung Li, Yu-Chen Hu. CRISPR activation of long non-coding RNA DANCR promotes bone regeneration. Biomaterials. 2021 Aug; 275:120965. (SCI, IF: 12.479, Engineering, Biomedical, Rank: 3/90)(Co-first author)

6

Yi-min Hsiao, Chih-Chien Hu, Mei-Feng Chen, Chih-Hsiang Chang, Yu-Tien Chiu, Chang YH*. Serum Insufficiency Induces RANKL-Independent Osteoclast Formation during Developing Ischemic ONFH. Biomedicines. 2021 Jun; 9(6): 685. (SCI, IF: 6.081, Pharmacology & Pharmacy, Rank: 33/275) (Corresponding author)

7

Jui-Ping Chen, Chih-Hsiang Chang, Yu-Chih Lin, Sheng-Hsun Lee, Hsin-Nung Shih, Chang YH*.Two-stage exchange Arthroplasty for knee Periprosthetic joint infection exhibit high infection recurrence rate in patients with chronic viral hepatitis. BMC Musculoskelet Disord. 2021 Jun 12;22(1):538. (SCI, IF: 2.362, Orthopedics , Rank: 41/82) (Corresponding author)

8

Chang YH , Chih-Chien Hu, Ying-Yu Wu, Steve W N Ueng, Chih-Hsiang Chang, Mei-Feng Chen. Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity. Int J Mol Sci. 2021 Jan 25;22(3):1169. (SCI, IF: 5.923, Biochemistry & Molecular Biology, Rank: 67/298) (First author)

9

Chang YH, Mel S. Lee, Jiann-Jong Liau, Yu-Liang Liu, Wen-Chuan Chen and Steve W. N. Ueng*. Polyethylene-Based Knee Spacer for Infection Control: Design Concept and Pre-Clinical In Vitro Validations. Polymers (Basel). 2020 Oct 13;12(10):2334. (SCI, IF : 4.329, POLYMER SCIENCE, Rank : 18/88) (First author)

10

Hsu MN, Yu FJ, Chang YH, Huang KL, Pham NN, Truong VA, Lin MW, Nuong Thi Kieu Nguyen, Hwang SM, Hu YC. CRISPR interference-mediated noggin knockdown promotes BMP2-induced osteogenesis and calvarial bone healing. Biomaterials. 2020 Sep; 252: 120094. (SCI, IF: 12.479, Engineering, Biomedical, Rank: 3/90) (First author)
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