1 Global leading PI:
 A Multi-centre Phase II, Double-Blind, Randomised Study of Savolitinib in Combination with Osimertinib vs Savolitinib in Combination with Placebo in Patients with EGFRm+ and MET Amplified Locally Advanced or Metastatic Non-Small Cell Lung Cancer who have Progressed Following Treatment with Osimertinib(NCT04606771)
o Drug: Savolitinib
 A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) in Participants With Treatment-naïve, Metastatic Nonsmall Cell Lung Cancer (NSCLC) Whose Tumors Have a Tumor Proportion Score (TPS) Greater Than or Equal to 1% (LEAP-007)(NCT03829332)
o Drug: Lenvatinib
 A Phase I/II, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics and Anti-tumor Efficacy of DZD9008 in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) with EGFR or HER2 mutation (NCT03974022)
o Drug: DZD9008
 A Multicenter, Open-Label Phase 1 Study of DS-1205c in Combination With Osimertinib in Subjects With Metastatic or Unresectable EGFR-Mutant Non-Small Cell Lung Cancer(NCT03255083)
o Drug: DS-1205c
 A Phase 1, open-label,Multicentre Study to assess the, tolerability, Pharmacokinetics and Preliminary Anti-Tumor Activity of AZD3759 or AZD9291 in Patients with EGFR Mutation Positive advanced stage NSCLC(NCT02228369)
o Drug: AZD3759
 A Phase III, Multi-Centre, Open Label, Randomized Study to Assess the Efficacy and Safety of AZD9291 in Combination With MEDI4736 Versus AZD9291 Monotherapy in Patients With Locally Advanced or Metastatic Epidermal Growth Factor Receptor T790M Mutation-positive Non-Small Cell Lung Cancer Who Have Received Prior Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy (CAURAL)(NCT02454933)
o Drug: AZD9291 and MEDI4736
 LUX-Lung 2: a phase II trial evaluating afatinib in NSCLC patients with EGFR mutations, either treatment-naïve or after one line of treatment with chemotherapy.(NCT00525148)
o Drug: BIBW 2992 (Afatinib)
 LUX-Lung 1: a phase IIb/III trial investigating afatinib plus best supportive care (BSC) versus placebo plus BSC in NSCLC patients who were previously treated with first-line chemotherapy and the reversible EGFR tyrosine kinase inhibitors (TKIs) erlotinib or gefitinib. (note: gefitinib is not available in the US) (NCT00656136)
o Drug: BIBW 2992 (Afatinib)
 LUX-Lung 3: a phase III trial investigating afatinib as a first-line treatment in patients with advanced NSCLC with EGFR mutations. (NCT00949650)
o Drug: BIBW 2992 (Afatinib)
2 Steering committee member:
 A Phase 1/2 Study of NM21-1480 (Anti-PDL-1/Anti-4-1BB/Anti-HSA Tri-Specific Antibody) in Adult Patients With Advanced Solid Tumors (NCT04442126)
o Biological: NM21-1480
 An Open-label Phase 1/1b Study to Evaluate the Safety and Pharmacokinetics of JNJ-73841937 (Lazertinib), a Third Generation EGFR-TKI, as Monotherapy or in Combinations With JNJ-61186372, a Human Bispecific EGFR and cMet Antibody in Participants With Advanced Non-Small Cell Lung Cancer (NCT04077463),
o Drug: Lazertinib and Amivantamab
 A Multi-centre Phase II, Double-Blind, Randomised Study of Savolitinib in Combination With Osimertinib vs Savolitinib in Combination With Placebo in Patients With EGFRm+ and MET Amplified Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed Following Treatment With Osimertinib (NCT04606771),
o Drug: Savolitinib
 A Phase 1/2a, Open-Label, Multi-Center Trial to Assess Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of CLN-081 in Patients With Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations (NCT04036682),
o Drug: CLN-081
 A Phase 1/2, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 510 Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and AMG 510 Combination Therapy in Subjects With Advanced NSCLC With KRAS p.G12C Mutation (CodeBreaK 100) (NCT03600883)
o Drug: AMG 510
 A Phase II, Two-arm Study to Investigate Tepotinib Combined With Osimertinib in MET Amplified, Advanced or Metastatic NSCLC Harboring Activating EGFR Mutations and Having Acquired Resistance to Prior Osimertinib Therapy (INSIGHT 2) (NCT03940703)
o Drug: Tepotinib
 A Phase 1/2 Study of the Safety, Pharmacokinetics, and Anti-Tumor Activity of the Oral EGFR/HER2 Inhibitor TAK-788 (AP32788) in Non-Small Cell Lung Cancer(NCT02716116)
o Drug: TAK-788
 A Randomized, Double-blind, Placebo-controlled, Phase III Study Evaluating the Efficacy and Safety of Canakinumab in Combination With Docetaxel Versus Placebo in Combination With Docetaxel in Adult Subjects With Non-small Cell Lung Cancer (NSCLC) Previously Treated With PD-(L)1 Inhibitors and Platinum-based Chemotherapy (CANOPY 2)(NCT03626545)
o Drug: Canakinumab
 A Phase 3 Randomized Open-label Study of Brigatinib (ALUNBRIG®) Versus Alectinib (ALECENSA®) in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer Patients Who Have Progressed on Crizotinib (XALKORI®)(NCT03596866)
o Drug: Brigatinib
 Phase II, Open Label, Single Arm Study of the Efficacy and Safety of Crizotinib in East Asian Patients With Advanced ALK-Negative NSCLC Harboring a Translocation or Inversion Involving the c-ROS Oncogene (ROS1) Locus (NCT01945021)
o Drug: Crizotinib
 A Phase 2 Precision Oncology Study of Biomarker-Directed, Pembrolizumab-(MK-3475, SCH 900475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (KEYNOTE-495; KeyImPaCT)( (NCT03516981)
o Drug: Lenvatinib and Pembrolizumab
 A Phase 1/2, Open-label, Multicenter Study to Evaluate Safety, Tolerability, Pharmacokinetics and Efficacy of HS-10296 in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer(NCT02981108)
o Drug: HS-10296
 LUX-Lung 7 (Clinical Trial Identifier NCT01466660): a phase IIb trial evaluating afatinib head-to-head versus gefitinib as a first-line treatment in patients with advanced NSCLC with EGFR mutations.
o Drug: Afatinib
 A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor (TKI) Therapy (CheckMate722) (NCT02864251)
o Drug: Nivolumab + Ipilimumab
3 Advisory board:
 A Phase I, Open-label, Non-randomised Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of a Single Oral Dose of AZD9291 in Patients With EGFRm Positive NSCLC Whose Disease Has Progressed on an EGFR TKI (NCT02157883)
o Drug: AZD9291
 An Open-label, Randomized Phase 3 Efficacy Study of ASP8273 vs Erlotinib or Gefitinib in First-line Treatment of Patients With Stage IIIB/IV Non-small Cell Lung Cancer Tumors With EGFR Activating Mutations (NCT02588261)
o Drug: ASP8273
 A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignancies (NCT02108964)
o Drug: EGF816
 A Phase III, Open-label, Multicenter Trial of Avelumab (MSB0010718C) Versus Platinum-based Doublet as a First-line Treatment of Recurrent or Stage IV PD-L1+NSCLC (NCT02576574)
o Drug: Avelumab
 GioTag: Real-world Data Study on Sequential Therapy With Gi(l)Otrif®/ Afatinib as First-line Treatment Followed by Osimertinib in Patients With EGFR Mutation Positive Advanced Non-small Cell Lung Cancer (NCT03370770)
o Drug: Afatinib
 A phase I/II study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Lung Cancer (MK-3475-021/KEYNOTE-021)　(NCT02039674)
o Drug: Pembrolizumab
 A phase I/II, multicenter, open-label study of EGF816(EGFR-TKI) in adult patients with EGFR-mutant solid malignancies(NCT02108964)
o Drug: EGF816
 Phase 2, open-label, single-arm study of the efficacy and safety of CRIZOTINIB in east asian patients with advanced ALK-negative non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the c-ros oncogene (ROS1) locus (NCT01945021)
o drug: Crizotinib
 Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of AZD9291 in Patients With Advanced Non Small Cell Lung Cancer Who Progressed on Prior Therapy With an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Agent (NCT01802632)
o Drug: AZD9291
 A Phase IB/II, Open Label, Multicenter Study of INC280 Administered Orally in Combination With Gefitinib in Adult Patients With EGFR Mutated, c-MET-amplified Non-small Cell Lung Cancer Who Have Progressed After EGFR Inhibitor Treatment (NCT01610336)
o Drug: INC280
4 Involved in or cooperated with international organizations, conferences
5 Invited Reviewer of Manuscripts: New England Journal of Medicine, Lancet Oncology, Lancet Respiratory Medicine, Journal of Clinical Oncology, Nature Communication, Journal of Thoracic oncology, Cancer Research, Clinical Cancer Research, Lung Cancer, Urologic Oncology, Cancer Letter
6 Highly cited researcher of 2019 and 2020 in Clinical Medicine category awarded by Clarivate Analytics (Web of Science Group).
World’s Top 2% Scientists 2020 and the 4th scientist among the Taiwanese Top 2% Scientists 2020.