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Principal Investigator


National Taiwan University Hospital (在職)

Division of Neurology

更新時間:2023-09-19

林靜嫻LIN, CHIN-HSIEN
  • Principal Investigator
  • Clinical Trial Experience (year) 12 years 9 個月

Highlights

Dr. Lin is a professor in Department of Neurology, National Taiwan University Hospital. Her main research interests include Parkinson’s disease (PD), movement disorders, neurodegenerative disorders and young-onset Parkinson’s disease. Dr. Lin is active in many steering committees of International Movement Disorder Society. In addition to clinical studies, Dr. Lin investigated the molecular mechanisms of mutations of Parkinson’s disease or dystonia causative genes in neuronal degeneration by using cellular and animal model systems, and also involved in establishing biomarkers reflecting disease progression of Parkinson’s disease. Dr. Lin has established transgenic Drosophila and mice model of PD to investigate the molecular mechanism leading to neurodegeneration. Based on these PD models, Dr. Lin has screened a bank of FDA-approven drug library and identified Lovastatin could mitigate dopaminergic neuron degeneration. Dr. Lin then raised a principal-investigator initiated phase II, double-blind, placebo controlled clinical trial exploring the neuroprotective effects of Lovastatin in patients with early-stage and drug naive PD. The results showed a beneficial effects and contributes to the mechanism-targeted therapy in the field of PD. Dr. Lin was invited to share the result of this trial in the 13th Alzheimer's & Parkinson's Diseases Congress - AD/PD™ in Vienna, Austria in 2017. She is now a leading PI in a phase II trial for a novel 18F-PMPBB3 (APN-1607) PET imaging tracer in differentiating patients with Parkinsonism syndrome from PD. Dr. Lin is now serving as a president of Taiwan Movement Disorder Society.

Study Area

  • Parkinson's disease and Movement disorders
  • Neurodegenerative disorders
  • Progressive supranuclear palsy
  • Corticobasl syndrome
  • Dystonia
  • Wilson's disease

Professional Experiences

National Taiwan University

Clinical Professor

Department of Neurology, College of Medicine

2020- 迄今

National Taiwan University Hospital

Attending Physician

Department of Neurology

Education

National Taiwan University

Graduate Institute of Clinical Medicine, College of Medicine

Ph.D.

National Taiwan University

School of Medicine, College of Medicine

M.D.

Clinical Trials List

See All8Cases

2016

Total 8

  • I 0

  • I/II 0

  • II 4

  • II/III 0

  • III 3

  • IV 0

  • Others 1

Number of Studies by Scale

0件

Taiwan Multiple Center

Taiwan Single Center

4Cases

Taiwan Multiple Center

0Cases

Multi-Regional Multi-Center

4Cases