Clinical Trials List
Protocol Number202006173MINB
NCT Number(ClinicalTrials.gov Identfier)N/A
2021-01-01 - 2021-12-31
Others
Recruiting1
ICD-10I67.89
Other cerebrovascular disease
Investigating clinical features and biomarkers of parkinsonism in CADASIL patients
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Trial Applicant
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Sponsor
National Taiwan University Hospital
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Trial scale
Taiwan Single Center
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Update
2025/08/20
Investigators and Locations
Co-Principal Investigator
- MEI-FANG CHENG Division of Nuclear Medicine
- SUNG-CHUN TANG Division of Neurology
The Actual Total Number of Participants Enrolled
0 Recruiting
Condition/Disease
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)
Objectives
To investigate whether parkinsonism features, or vascular parkinsonism, is presented as an important clinical manifestation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and to identify relevant blood and neuroimaging biomarkers associated with parkinsonism in CADASIL.
Test Drug
13N-NH3
Active Ingredient
13N-NH3
Dosage Form
IVT
Dosage
37-74
Endpoints
To investigate the effects of plasma and nuclear imaging biomarkers on the parkinsonism features among CADASIL patients.
To elucidate potential application of 13N-ammonia PET on brain perfusion in cerebral small vessel disease.
To elucidate potential application of 13N-ammonia PET on brain perfusion in cerebral small vessel disease.
Inclution Criteria
1) > 20 years old
2) with NOTCH3 mutation after genetic testing confirm
2) with NOTCH3 mutation after genetic testing confirm
Exclusion Criteria
1) Due to contraindications or unable to cooperate with the MRI examination
2) Unable to cooperate with 13N-ammonia positron radiography (for example, unable to lie flat or have claustrophobia)
3) Pregnant women
4) People whose life expectancy does not exceed one year due to serious physical illness
5) Those who are not suitable for other factors evaluated by the doctor
2) Unable to cooperate with 13N-ammonia positron radiography (for example, unable to lie flat or have claustrophobia)
3) Pregnant women
4) People whose life expectancy does not exceed one year due to serious physical illness
5) Those who are not suitable for other factors evaluated by the doctor
The Estimated Number of Participants
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Taiwan
90 participants
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Global
90 participants
