Clinical Trials List
Protocol Number201804036MINB
NCT Number(ClinicalTrials.gov Identfier)N/A
2018-08-01 - 2023-07-31
Others
Recruiting2
ICD-10I63.9
Cerebral infarction, unspecified
Investigation of post-stroke neurogenesis using rodent models and patients
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Trial Applicant
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Sponsor
National Taiwan University Hospital
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Trial scale
Taiwan Single Center
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Update
2025/08/20
Investigators and Locations
Principal Investigator
Co-Principal Investigator
- 蔡欣熹 Division of Neurology
The Actual Total Number of Participants Enrolled
0 Recruiting
Co-Principal Investigator
- SUNG-CHUN TANG Division of Neurology
- Jiann-Shing Jeng Division of Neurology
- RUOH-FANG YEN Division of Nuclear Medicine
The Actual Total Number of Participants Enrolled
0 Recruiting
Condition/Disease
post-stroke
Objectives
(1) To use 18F-FLT PET on different types of stroke models, including MCAO, ICH, and SAH, for investigation of the location, timing, pathological correlation, and significance on outcome of cerebral neurogenesis;
(2) To enroll different types of stroke patients, including cerebral infarct, ICH, and SAH, and use 18F-FLT PET to study the relationship between neurogenesis and stroke severity as well as post-stroke functional outcome.
Test Drug
18F-FLT
Active Ingredient
3′-deoxy-3′-[18F]-fluorothymidine radio tracer
Dosage Form
injection
Dosage
0.07mCi (2.59MBq)/kg; around 5mCi
Endpoints
(1) To use 18F-FLT PET on different types of stroke models, including MCAO, ICH, and SAH, for investigation of the location, timing, pathological correlation, and significance on outcome of cerebral neurogenesis;
(2) To enroll different types of stroke patients, including cerebral infarct, ICH, and SAH, and use 18F-FLT PET to study the relationship between neurogenesis and stroke severity as well as post-stroke functional outcome.
(2) To enroll different types of stroke patients, including cerebral infarct, ICH, and SAH, and use 18F-FLT PET to study the relationship between neurogenesis and stroke severity as well as post-stroke functional outcome.
Inclution Criteria
Inclusion criteria:
This study will include 120 stroke patients and 30 healthy volunteers:
1. Patients with age above 20 years old having stroke, which has been characterized by clinical assessment and head CT or MRI studies.
2. The stroke (ischemic stroke at middle cerebral artery territory; supratentorial ICH; or SAH without delayed cerebral ischemia) at post-stroke 7-14 days.
3. Healthy volunteers with age above 20 years old and without a past history of stroke.
4. Patient and family agree to participate in the study and receive cerebral 18F-FLT PET study.
This study will include 120 stroke patients and 30 healthy volunteers:
1. Patients with age above 20 years old having stroke, which has been characterized by clinical assessment and head CT or MRI studies.
2. The stroke (ischemic stroke at middle cerebral artery territory; supratentorial ICH; or SAH without delayed cerebral ischemia) at post-stroke 7-14 days.
3. Healthy volunteers with age above 20 years old and without a past history of stroke.
4. Patient and family agree to participate in the study and receive cerebral 18F-FLT PET study.
Exclusion Criteria
Exclusion criteria:
Patients with any of the following conditions will be excluded:
(1) Patients could not receive the PET study because of poor cooperative agitation impeding adequate study, hemodynamic instability, panic mood to PET study or any unstable clinical condition impeding receiving PET study.
(2) Patients with pregnancy or recently having a plan for pregnancy.
(3) Patient or family who does not agree to participate in the study.
Patients with any of the following conditions will be excluded:
(1) Patients could not receive the PET study because of poor cooperative agitation impeding adequate study, hemodynamic instability, panic mood to PET study or any unstable clinical condition impeding receiving PET study.
(2) Patients with pregnancy or recently having a plan for pregnancy.
(3) Patient or family who does not agree to participate in the study.
The Estimated Number of Participants
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Taiwan
150 participants
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Global
0 participants
